On October 20, 2008, developer THQ released the first video game, titled Are You Smarter than a 5th Grader?: Make the Grade, for the PC, PS2, Nintendo DS, Wii, and Xbox Live Arcade. The Xbox Live Arcade version as of mid-2010 was delisted from the Xbox Live Game Marketplace.
A sequel Are You Smarter than a 5th Grader? Game Time was released on October 26, 2009, for Nintendo DS, Wii and Xbox 360.
Capcom Mobile released a game based on the game show for iOS devices called "Are You Smarter than a 5th Grader 2010" in 2009.
In 2012, Ludia released a free game based on the game show called "Are You Smarter than a 5th Grader? & Friends" for iOS devices.
In 2015, GameMill Entertainment released a game based on the 2015 FOX Primetime revival for the Nintendo 3DS.
A version for PC, PlayStation 4, Nintendo Switch, PlayStation 5, and Xbox Series X/Xbox One, developed and published by THQ Nordic subsidiaries Massive Miniteam and HandyGames, was listed on Steam and Amazon in 2022.