Resembling other cooking games such as Cooking Mama, Supreme Cuisine features "a series of fast-paced and intense culinary challenges" in which players either use the Wii Remote or the stylus on the DS to prepare dishes while competing against an opponent. Much like the show, players must complete between three and six dishes within a time limit, which are then judged by taste, visual appeal, and originality.
The game features a chef school for the player to practice their skills in preparing dishes, a career mode in which players progress through a number of challengers before taking on the Iron Chefs, and an instant action quick play mode. The DS version features wireless multiplayer and a single-console "Pass Play" turn-based multiplayer mode.
The game features the voice acting and likeness of Chairman Mark Dacascos, commentator Alton Brown and Iron Chefs Mario Batali, Masaharu Morimoto and Cat Cora, whom players can either play as or compete against.