From Wikipedia: After Megamind becomes the hero of Metro City, Minion tells him that a group of villains known as the Doom Syndicate took Metro Man and Megamind's DNA. Megamind must defeat them and save Metro City. He first investigates the city streets, taking down the Construction Worker, then defeating Psycho Delic in the sewers, and finally Hot Flash downtown. Collecting the parts for his battle suit, Megamind confronts Tighten, his power restored and infused with Megamind's intelligence. Megamind still manages to defeat him at City Hall by collapsing parts of the building on him, weakening him enough for Megamind to use a serum to revert Hal back to normal. Megamind is victorious.