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From Wikipedia:
Syphon Filter: The Omega Strain is a third-person shooter stealth video game developed by Bend Studio and published by Sony Computer Entertainment exclusively for the PlayStation 2.
This is the first game in the series to not feature co-creator Richard Ham who had left Bend Studio after completing Syphon Filter 3 in 2001. John Garvin continued to work on the series until his own departure in 2019.