New to the series is the "My Player" feature, a career mode in which the player shepherds a player's career from the minors to the majors. Other features from the previous game have been improved or tweaked, including hitting and pitching. The game also features "MLB Today", an online ticker that tracks real-life Major League Baseball news and scores. With the MLB Today feature you can also play the same game that is being played in the real MLB. For example, if the New York Yankees are playing the Boston Red Sox and CC Sabathia is pitching, in the game he will be pitching along with the same lineup that is being used.
The commentary has been improved as well, which analyze stats from the current year, the previous year, the previous series, and so forth. The crowd noise has also been reworked and sounds better than any previous version.
The Franchise Mode has been enhanced as well. Players can choose multiple teams and run their franchise, and can make staff personnel decisions. There are now 40 man rosters for Spring Training and September call ups. Players also have a minor league system that run from Single A through Triple A. Players can draft players from the high school, college, and amateur league level. Teams now receive compensatory draft picks from Type A and B free agents as well. Players can invite friends to play against them within the Franchise Mode, as well as online player updates.
Like NBA 2K10, Major League Baseball 2K10 celebrates its 10th anniversary, going back to its Sega Dreamcast origins as World Series Baseball, though the series began in 1994 with the Sega Genesis release of World Series Baseball.